Endocrine Abstracts

Introduction: Myxedema coma is a rare life-threatening clinical condition in patients with longstanding severe untreated hypothyroidism, in whom adaptive mechanisms fail to maintain homeostasis. Most patients, however, are not comatose, and, although strict criteria have been proposed, it is often difficult to differentiate it from very severe hypothyroidism, lacking only a precipitating event.Material and methods: We present the clinical picture of 70 c...

Introduction: Nivolumab is an anti-programmed cell death-1 monoclonal antibody approved for the treatment of metastatic malignant melanoma. Several endocrine disorders have been reported as immune-related adverse effects. However, nivolumab-induced hypophysitis has a lower incidence than ipililumab.Case report: A 69-years old man with metastatic melanoma started to receive nivolumab. Ten weeks after the first cycle of nivolumab he presented hyperthyroidi...

Introduction: Bilateral sampling of the inferior petrosal sinuses is an accurate test to diagnose Cushing’s disease and distinguish it with the ectopic ACTH syndrome. The aim of the study was to review the petrosal sinus samplings carried out during last 10 years in our hospital.Methods and material: The medical histories of patients admitted for suspected Cushing’s disease in the last 10 years (from 2005 till 2015) were reviewed. There were se...